Goldberg Lab


View a full list of our publications on PubMed.

Rojas-Lopez M, Zajac AS, Wood TE, Miller KA, Gil-Marqués ML, Hachey AC, Kharbanda V, Egger KT, Goldberg MB. NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages. Sci Immunol. 2023. Full text:

Liew MY, Mathews JI, Li A, Singh R, Jaramillo SA, Weiss ZF, Bowman K, Ankomah PO, Ghantous F, Lewis GD, Neuringer I, Bitar N, Lipiner T, Dighe AS, Kotton CN, Seaman MS, Lemieux JE Goldberg MB. Delayed and attenuated antibody responses to COVID-19 vaccination with poor cross-variant neutralization in solid organ transplant recipients – a prospective longitudinal study. Open Forum Infectious Diseases. 2023. Accepted.

Wood TE, Westervelt KA, Yoon JM, Eshleman HD, Levy R, Burnes H, Slade DJ, Lesser CF, Goldberg MB. The Shigella spp. type III effector protein OspB is a cysteine protease. mBio. 2022; 13(3):e01270-22. PMC9239218.

Leisman DE, Privratsky JR, Lehman JR, Abraham MN, Yaipan OY, Brewer MR, Nedeljkovic-Kurepa A, Capone CC, Fernandes TD, Griffith R, Stein WJ, Goldberg MB, Crowley SD, Bellomo R, Deutschman CS, Taylor MD. Angiotensin II enhances bacterial clearance via myeloid signaling in a murine sepsis model. Proc Natl Acad Sci USA. 2022; 119(34):e2211370119. PMC9407661.

Boucau J, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Lipiner T, Kittilson A, Melberg M, Li Y, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Goldberg MB, Vyas JM, Li JZ, Lemieux JE, Siedner MJ, Barczak AK. Duration of shedding of culturable virus in SARS-CoV-2 Omicron (BA.1) infection. N Engl J Med. 2022; 387(3):275-277. PMC9258747.

Leisman DE, Mehta A, Thompson BT, Charland NC, Gonye ALK, Gushterova I, Kays KR, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Filbin MR, Goldberg MB.
Alveolar, endothelial, and organ injury marker dynamics in severe COVID-19.
Am J Respir Crit Care Med. 2021; 205(5):507–519. PMC8906476.

Chen P, Russo BC, Duncan-Lowey JK, Bitar N, Egger K, Goldberg MB.
Topology and contribution to the pore channel lining of plasma membrane-embedded Shigella flexneri type 3 secretion translocase IpaB.
mBio. 2021;e0302121. PMC8609354. 10.1128/mBio.03021-21

Fenyves BG, Mehta A, MGH COVID-19 Collection & Processing Team, Kays K, Goldberg MB, Hacohen N, Filbin M.
Plasma P-selectin is an early marker of thromboembolism in COVID-19.
Am J Hematol. 2021; 96(12):E468-E471. PMC8616847. 10.1002/ajh.26372

Russo BC, Duncan-Lowey JK, Chen P, Goldberg MB.
The type 3 secretion system requires actin polymerization to open translocon pores.

PLoS Pathog. 2021 Sep 9;17(9):e1009932. PMC8454972. 10.1371/journal.ppat.1009932

Kaplonek P, Wang C, Bartsch Y, Fischinger S, Gorman MJ, Bowman K, Kang J, Dayal D, Martin P, Nowak R, Hsieh CL, Feldman J, Julg B, Nilles EJ, Musk ER, Menon AS, Fischer ES, McLellan JS, Schmidt A, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Villani A-C, Sade-Feldman M, Goldberg MB, Filbin M, Hacohen N, Lauffenburger DA, Alter G.
Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19.
Sci Immunol. 2021;6(64):eabj2901. 10.1126/sciimmunol.abj2901

Leisman D, Mehta A, Li Y, Kays KR, Li JZ, Filbin MR, Goldberg MB.
Vasopressin infusion in COVID-19 critical illness is not associated with impaired viral clearance: a pilot study.
Br J Anaesth. 2021 Oct;127(4):e146-e148. PMC8289704. 10.1016/j.bja.2021.07.005

Piantadosi A, Mukerji SS, Ye S, Leone MJ, Freimark LM, Park D, Adams G, Lemieux J, Sanjat Kanjilal S, Solomon IH, Ahmed AA, Goldstein R, Ganesh V, Ostrem B, Cummins KC, Thon JM, Kinsella CM, Rosenberg E, Frosch MP, Goldberg MB, Cho TA, Sabeti P.
Enhanced virus detection and metagenomic sequencing in patients with meningitis and encephalitis.
mBio. 2021;12(4):e0114321. PMC8406231. 10.1128/mBio.01143-21

Reyes M, Filbin MR, Bhattacharyya RP, Sonny A, Mehta A, Billman K, Kays KR, Pinilla-Vera M, Benson ME, Cosimi LA, Hung DT, Levy BD, Villani A-C, Sade-Feldman M, Baron RM, Goldberg MB, Blainey PC, Hacohen N.
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Sci Transl Med. 2021; 13(598):eabe9599. PMC8432955. 10.1126/scitranslmed.abe9599

Li Y, Schneider AM, Mehta A, Sade-Feldman M, Kays KR, Gentili M, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Parry BA, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Regan J, Flynn JP, Villani A-C, Hacohen N, Goldberg MB, Filbin MR, Li JZ.
SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes.
J Clin Invest. 2021;131(13):e148635. PMC8245177. 10.1172/JCI148635

Filbin MR#, Mehta A#, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Parry BA, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Gerszten RE, Heimberg GS, Hoover PJ, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M, Smillie CS, Waghray A, Wood TE, Zajac AS, Jennings LL, Grundberg I, Bhattacharyya RP, Parry BA, Villani A-C, Sade-Feldman M, Hacohen N#, Goldberg MB#.
Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients.
Cell Rep Med. 2021; 2(5):100287. PMC8091031.

Meyerowitz EA, Sanchez S, Mansour MK, Triant VA, Goldberg MB.
Isolated cerebral mucormycosis in immunocompetent adults who inject drugs: case reports and systemic review of the literature.
Open Forum Infectious Diseases. 2020. 7(12), ofaa552. PMC7765436.

Duncan-Lowey JK, Wiscovitch AL, Wood TE, Goldberg MB#, Russo BC#.
Shigella flexneri disruption of cellular tension promotes intercellular spread.
Cell Rep. 2020; 33(8):108409. PMC7792532. #Co-corresponding authors.

Kutsch M, Sistemich L, Lesser CF, Goldberg MB, Herrmann C, Coers J.
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.
EMBO J. 2020; 39(13):e104926. PMC7327485.

Shrock E, Fujimura,…Goldberg MB, et al.
Viral epitope profiling in COVID-19 patients reveals cross-reactivity and correlates of severity.
Science. 2020 Nov 27; 370(6520):eabd4250. doi: 10.1126/science.abd4250. PMC7857405.

Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC#, Goldberg MB#, Hacohen N#.
An immune cell signature of bacterial sepsis.
Nat Med. 2020 26:333-340. PMC7235950. #Co-corresponding authors.

Russo BC, Duncan JK, Wiscovitch AL, Hachey AC, Goldberg MB.
Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore.
PLoS Pathog. 2019; 15:e1007928. PMC6879154.

Russo BC, Duncan JK, Goldberg MB.
Topological analysis of the type 3 secretion system translocon pore protein IpaC following its native delivery to the plasma membrane during infection.
mBio. 2019 May 28;10(3). pii: e00877-19. doi: 10.1128/mBio.00877-19. PMC6538787. *Editor’s Pick.

Piantadosi A, Kanjilal S, Ganesh V, Khanna A, Hyle EP, Rosand J, Bold T, Metsky HC, Lemieux J, Leone MJ, Freimark L, Matranga CB, Adams G, McGrath G, Zamirpour S, Telford S 3rd, Rosenberg E, Cho T, Frosch MP, Goldberg MB, Mukerji SS, Sabeti PC.
Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing.
Clin Infect Dis. 2018;66:789-792. PMC5850433.

Miller KA, Garza-Mayers AC, Leung Y, Goldberg MB.
Identification of interactions among host and bacterial proteins and evaluation of their role early during Shigella flexneri.
Microbiology. 2018; 164:540-550. DOI: 10.1099

Piantadosi A, Mukerji SS, Chitneni P, Cho TA, Cosimi LA, Hung DT, Goldberg MB, Sabeti PC, Kuritzkes DR, Grad YH.
Metagenomic sequencing of an echovirus 30 genome from cerebrospinal fluid of a patient with aseptic meningitis and orchitis.
Open Forum Infectious Diseases. 2017. 4:ofx138. PMC5524216.

Russo BC, Stamm LM, Raaben M, Kim CM, Kahoud E, Robinson LR, Bose S, Queiroz AL, Herrera BB, Baxt LA, Mor-Vaknin N, Fu Y, Molina G, Markovitz DM, Whelan SP, Goldberg MB. Intermediate filaments enable pathogen docking to trigger type 3 effector translocation.
Nat Microbiol. 2016. Article No. 16025; DOI: 10.1038. PMC5006386.

Lu R, Herrera BB, Eshleman HD, Fu Y, Bloom A, Li Z, Sacks DB, Goldberg MB.
Shigella effector OspB activates mTORC1 in a manner that depends on IQGAP1 and promotes cell proliferation.
PLoS Pathogens. 2015; 11(10):e1005200. PMC4608727.

Lee SY, Gertler FB, Goldberg MB.
Vasodilator-stimulated phosphoprotein (VASP) restricts cell-to-cell spread of Shigella flexneri at the cell periphery.
Microbiology. 2015; 161:2149-2160. PMC4806587.

Garza-Mayers AC, Miller KA, Russo BC, Nagda DV, Goldberg MB.
Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.
mBio. 2015; 6(2). pii: e02584-14. PMC4358011

Yi C-R, Allen JE, Russo B, Lee SY, Heindl JE, Baxt LA, Herrera BB, Kahoud E, MacBeath G, Goldberg MB.
Systematic analysis of bacterial effector-postsynaptic density 95/discs large/zonula occludens-1 (PDZ) interactions demonstrates Shigella OspE promotes PKC activation via PDLIM proteins.
J Biol Chem. 2014; 289:30101-30113. PMC4208017

Baxt LA, Goldberg MB.
Host and bacterial proteins that repress recruitment of LC3 to Shigella early during infection.
PLoS One. 2014;9(4):e94653. PMC3983221

Li Z, Boyd D, Reindl M, Goldberg MB.
Identification of YidC residues that define interactions with the Sec Apparatus.
J Bacteriol. 2014;196(2):367-77. PMC3911256

Gray AN, Li Z, Henderson-Frost J, Goldberg MB.
Biogenesis of YidC cytoplasmic membrane substrates is required for positioning of autotransporter IcsA at future poles.
J Bacteriol. 2014;196(3):624-32. PMC3911155

Baxt LA, Garza-Mayers AC, Goldberg MB.
Bacterial subversion of host innate immune pathways.
Science. 2013;340(6133):697-701.

Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ.
The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium.
Cell Host Microbe. 2012;12(6):778-90. PMCID: PMC3785244

Fixen KR, Janakiraman A, Garrity S, Slade DJ, Gray AN, Karahan N, Hochschild A, Goldberg MB.
Genetic reporter system for positioning of proteins at the bacterial pole.
MBio. 2012;3(2). PMC3302567

Gray AN, Henderson-Frost JM, Boyd D, Shirafi S, Niki H, Goldberg MB.
Unbalanced charge distribution as a determinant for dependence of a subset of E. coli membrane proteins on the membrane insertase YidC.
MBio. 2011; 2(6): doi:10.1128/mBio.00238-11. PMC3911155

Stamm LM, Goldberg MB.
Establishing the secretion hierarchy.
Science. 2011 4;331(6021): 1147-1148.

Jehl S, Doling A, Giddings, KS, Phalipon A, Sansonetti PJ, Goldberg MB, Starnbach MN.
Antigen-specific CD8+ T cells fail to respond to Shigella flexneri.
Infect Immun. 2011: 79(5); 2021-2030. PMC3088127

Stamm LM, Heller DM, Goldberg MB.
Caging targets for destruction.
Cell Host Microbe. 2010: 8: 391-393

Baxt LA, Goldberg MB.
Anaerobic environment of the intestine primes pathogenic Shigella for infection.
Expert Rev Anti Infect Ther. 2010: 8(11): 1225-1229.

Lu R, Goldberg MB.
Bacterial Exploitation of Host Cell Signaling.
Sci Transl Med. 2010; 2(51): 48.

Heindl JE, Saran I, Yi CR, Lesser CF, Goldberg MB.
Requirement for formin-induced actin polymerization during spread of Shigella.
Infect Immun. 2009 Jan; 78(1):193-203. PMC2798232

Yi CR, Goldberg MB.
Enterohemorrhagic Escherichia coli raises the I-BAR.
Proc Natl Acad Sci USA. 2009; 106(16): 6431-2.

Yi CR, Goldberg MB.
Putting enterohemorrhagic E. coli on a pedestal.
Cell Host Microbe. 2009; 5(3): 215-7.

Janakiraman A, Fixen KR, Gray AN, Niki H, Goldberg MB.
A genome-scale screen identifies a role for DnaK in chaperoning of polar autotransporters in Shigella.
J Bacteriol. 2009; 191(20): 6300-6311. PMC2753027.

Wagner JK, Heindl JE, Gray AN, Jain S, Goldberg MB.
Contribution of the periplasmic chaperone Skp to efficient presentation of the autotransporter IcsA on the surface of Shigella flexneri.
J Bacteriol. 2009 Feb;191(3):815-821. PMC2632083